Abstract

OBJECTIVE

Strong collaboration between healthcare professionals and patients is necessary for the control of tuberculosis (TB), a potentially fatal and contagious disease without treatment. Our research aims to evaluate whether healthcare professionals have stigmatizing attitudes and behaviours toward TB patients.

MATERIAL AND METHODS

A web-based survey of 19 questions covering clinical situations was designed. A total of 528 healthcare professionals working in different healthcare institutions across the country participated in the survey. Stigma scores were recorded on a 5-point Likert response scale ranging from -2 to +2: the extreme points were ‘strongly disagree’ and ‘strongly agree’.

RESULTS

The highest stigma scores were observed in non-physician auxiliary healthcare personnel groups such as medical secretaries, social workers, dietitians, pharmacists, midwives, nurses, and nurse assistants, while the lowest scores were detected in specialist physicians and academic physicians. In demographic analyses, it was observed that healthcare workers (HCWs) who more often encounter TB cases have higher stigma scores. In addition, when evaluated according to the type of institution they work in, it was found that stigma levels were higher in pharmacies, clinics, individual medical practices, private and independent healthcare institutions, and workplaces.

CONCLUSION

This study can contribute to reducing the stigma levels of HCWs towards TB patients with effective training programs and appropriate health policies, thus improving the health services provided to patients.

INTRODUCTION

Tuberculosis (TB) control continues to maintain its importance in the 21^st century. Some of the reasons behind this are the increasing global climate crisis, the effects of regional conflicts and wars, mass human migrations, and disrupted TB control mechanisms during the Coronavirus disease-2019 (COVID-19) pandemic. Immigrants and refugees are more likely to disrupt TB treatments and accelerate the spread of TB in societies.^1-4 At this point, the attitudes and behaviours of healthcare professionals towards TB cases gain importance. Studies showed that, 80% of TB cases in various societies were subjected to stigma. It has been demonstrated that TB cases who encounter stigma tend to exhibit behaviours that will disrupt TB control and to avoid seeking medical help. Their compliance with TB treatment decreases.^{5, 6} This has led the World Health Organization to emphasize that TB stigma is a major obstacle to ending TB by 2050 and that all forms of discrimination in health should be eliminated.⁷

Due to professional ethics, it is more difficult to reveal the stigmatising attitudes and behaviours of health professionals towards TB cases, than to investigate society-based stigma. In addition, the negative attitudes of health professionals towards TB cases have a more negative effect on TB patients than the stigmatising attitudes of society.^{8, 9} In this context, we aimed to elucidate the attitudes and behaviours of health professionals towards TB patients and to reveal the reasons for stigma, if any.

MATERIAL AND METHODS

Ethics Approval

The survey was conducted between March and June 2024. All procedures adhered to the ethical standards of the responsible institutional and national committees on human experimentation, as well as the Helsinki Declaration of 1975, revised in 2008. Ethics committee approval was granted by University of Health Sciences Türkiye, Gazi Yaşargil Training and Research Hospital (protocol number: 920, date: 05.11.2021), and informed consent was obtained from all participants. The participants’ identities were kept confidential, and the data obtained were used only within the scope of this research.

Research Design

This study involved 528 healthcare workers (HCWs) from various provinces and hospitals. A 19-question survey, designed based on clinical situations observed by the researchers in the work environment, was used to measure the participants’ attitudes towards TB cases. Participants shared their opinions on TB-related clinical and work environments using a 5-point Likert scale. Only question 18 used a 3-point Likert-type scale with the options ‘Yes,’ ‘No,’ and ‘No idea,’ allowing participants to express opinions reflecting on their entire professional life. Responses were scored between “strongly disagree” and “strongly agree”, with a stigma score of -2 and +2 at the extremes. Participants’ demographic information such as age, gender, education level, specialty, institution type, and the number of patients seen annually was recorded (Table 1).

HCWs were recruited through a web-based approach. Invitations to participate in the survey were distributed via email and WhatsApp by the researchers, targeting healthcare professionals across various institutions in the country. Participation was voluntary, and all responses were anonymized to ensure confidentiality.

Study Participants

Participants were healthcare professionals from public, university, and private institutions, and individual healthcare facilities. They included midwives, nurses, nursing assistants, general practitioners (GPs), residents, specialist physicians, academic physicians, pharmacists, dietitians, dentists, laboratory technicians, social workers, and medical secretaries.

Data Collection and Processing Methods

Responses were scored from -2 to +2 stigma points, ranging from ‘strongly disagree’ to ‘strongly agree’. The frequency of the responses in each question was multiplied by the coefficient of that response according to the Likert scale, and the weighted frequency (WF) of the questions was calculated. Then, the WF values ​​were divided by the total number of participants and the Weighted Frequency Index (WFI) was obtained for each question. Since some WFI values ​​were outside -1 and +1, WFI values ​​were normalised by dividing them by the highest absolute value of WFI in our data set, thus obtaining the Normalized Weighted Frequency Index (NWFI) ranging from -1 to +1 (Table 2). WF, and NWFIs were calculated to assess stigma scores. These indices were determined by multiplying the frequency of each response by its corresponding stigma coefficient, summing the results, and then averaging them. The formulas and detailed calculations are provided in Appendix 1.

Statistical Analysis

The collected data were analyzed using Statistical Package for the Social Sciences 20.0 statistical software. Descriptive statistics were calculated for demographic data, and Mann-Whitney U and Kruskal-Wallis tests were applied for group comparisons. In the analysis of stigma scores, inverse values ​​were used to ensure that higher scores represented higher stigmatisation. Post-hoc analyses were performed by applying Mann-Whitney U tests between subgroups. The results were considered statistically significant when the P value was less than 0.05.

RESULTS

A total of 528 participants were included in the study. The mean age of the participants was 42.75 years [standard deviation (SD): 9.681], and the ages ranged from 23 to 79. The age distribution was approximately normal, with a skewness value of 0.287 (SD: 0.106). 23.1% (n = 122) of the participants were under 35 years of age, 53.4% (n = 282) were between 35 and 49 years of age, and 23.5% (n = 124) were 50 years of age and older. The gender distribution was 44.3% (n = 234) male and 55.7% (n = 294) female. According to the level of education, 0.4% (n = 2) of the participants were high school graduates, 1.9% (n = 10) had an associate degree, 22.9% (n = 121) had a bachelor’s degree, 50.8% (n = 268) had a master’s degree, and 24.1% (n = 127) had a doctorate. In the distribution by type of healthcare professionals, 8.5% (n = 45) were midwives, nurses, and nurse assistants, 26.7% (n = 141) were other healthcare professionals, 9.7% (n = 51) were GPs, 10% (n = 53) were residents, 30.5% (n = 161) were specialist physicians, and 14.6% (n = 77) were academic physicians. In terms of branch distribution, 48.1% (n = 254) are chest diseases specialists, 13.1% (n = 69) are specialists in internal medicine and its subspecialties, 11.2% (n = 59) are GPs and dentists, 16.7% (n = 88) are non-physician health workers and 11% (n = 58) work in the surgical branch. In terms of distribution by health service level, 12.5% ​​(n = 66) work in primary care, 18.9% (n = 100) in secondary care, and 68.6% (n = 362) in tertiary care (Table 3).

According to the type of institution, 48.9% (n = 258) of the participants work in a state institution, 22.3% (n = 118) in a university institution, 11.2% (n = 59) in a private institution, and 17.6% (n = 93) in other institutions or individually. In the distribution according to the number of cases seen annually, 54.1% (n = 285) see 1-30 cases, 5.5% (n = 29) see 31-100 cases, 4.9% (n = 26) see more than 100 cases, and 35.5% (n = 187) do not see any cases.

Non-parametric tests are conducted to examine the differences between demographic variables, including gender, age groups, education level, type of health worker, branches, health service level, type of institution, and annual number of cases.

No significant difference was found between genders (male and female) (P = 0.324). There was no significant difference between age groups (<35, 35-49, 50+), (P = 0.140). There was also no significant difference in the analyses conducted according to education levels (high school, associate degree, undergraduate degree, graduate degree, doctorate) (P = 0.156). Significant differences were found between types of HCWs (P < 0.001). The highest stigma score was found in the “other HCWs” group (mean rank 392.41), which included social workers, medical automation personnel, dietitians, and other non-physician HCWs. Similarly, significant differences were found between types of institutions (P < 0.001). “Other institutions” (mean rank 400.45), which included individual medical practice centres, dental clinics, pharmacies and similar institutions, stood out as the group with the highest stigma score.

Significant differences in annual case numbers were also observed (P < 0.001). Those with more than 100 cases (mean rank 410.25) had the highest stigma scores. No significant differences were found among other demographic variables. These results highlight the variability in stigma levels across specific demographic groups and institution types, and they suggest the need for targeted interventions to address stigma in particular groups.

Stigma Scores by Type of Healthcare Professionals

Nurses had significantly higher stigma scores compared to other healthcare professionals (P < 0.001) and academicians (P < 0.001). Other healthcare professionals had substantially higher stigma scores compared to GPs (P < 0.001), residents (P < 0.001), specialist doctors (P < 0.001), and academicians (P < 0.001). In addition, GPs had higher stigma scores compared to specialist doctors (P = 0.026) and academicians (P < 0.001), and residents had higher stigma scores compared to specialist doctors (P < 0.001) and academicians (P < 0.001). Specialist doctors also had significantly higher stigma scores compared to academics (P < 0.001). There was no significant difference between nurses and GPs (P = 0.458), nurses and residents (P = 0.124), nurses and specialist doctors (P = 0.079), and GPs and residents (P = 0.605) (Table 4).

In summary, the highest stigma scores were observed among non-physician “Other Healthcare Professionals” (mean rank 392.41), including social workers, medical automation personnel, and dietitians. In contrast, the lowest stigma scores were observed among specialist doctors (mean rank 206.18) and academic doctors (mean rank 148.70).

The ranking by type of healthcare professionals from high to low stigma score was as follows:

- Other HCWs (392.41)

- Residant (284.16)

- GP (266.58)

- Nurse (242.00)

- Specialist (206.18)

- Academic (148.70)

Stigma Scores by Institution Type

The post-hoc analyses revealed significant differences in stigma scores between various types of institutions. Notably, public institutions showed significant differences when compared to university institutions (P < 0.001), private institutions (P = 0.002), and other institutions (P < 0.001). Similarly, university and private institutions exhibited significant differences when compared to other institutions (P < 0.001). However, no significant difference was found between university institutions and private institutions (P = 0.210) (Table 5).

The order of highest to lowest stigma scores was as follows:

- Other institutions (average rank 273.30)

- University institutions (average rank 228.96)

- Private institutions (average rank 190.93)

- Public institutions (average rank 169.19)

These findings underscore variability in stigma levels and highlight the need for tailored interventions. Notably, public sector workers demonstrated lower stigma scores (202.36), while private or individual HCWs exhibited the highest stigma scores (400.45) (KW: 120.515, P < 0.001).

Stigma Scores According to Annual Number of Cases

The analysis of stigma scores according to the annual number of cases revealed significant differences. Specifically, significant differences were found among the following groups: 1-30 cases and 31-100 cases (P < 0.001), 1-30 cases and 100+ cases (P < 0.001), 31-100 cases and no cases (P < 0.001), and 100+ cases and no cases (P < 0.001). However, no significant difference was found between the groups with 1-30 cases and no cases (P = 0.838) and the groups with 31-100 cases and 100+ cases (P = 0.251). These results indicate that the number of annual cases has a significant impact on stigma levels. HCWs who handle more cases have higher stigma scores (410.25), while those who handle no cases have lower stigma scores (245.79), (KW: 43.399, P < 0.001) (Table 6).

Most and Least Stigmatizing Expressions

The study identified the highest and lowest stigmatizing expressions based on NWFI values (Table 7).

DISCUSSION

Higher levels of stigmatisation were observed among non-physician health personnel, including social workers, medical automation personnel, laboratory technicians, and dietitians, as well as in workplaces such as individual medical offices, dental clinics, and pharmacies. Increased stigma levels were associated with a higher number of cases. In contrast, lower stigma scores were found among academicians and specialist physicians and in public or state institutions.

Similar findings were obtained in a study by Sima et al.⁹ on 108 health workers in rural Ethiopia. The study assessed healthcare professionals’ knowledge, attitudes, and stigmatizing behaviors regarding TB, indicating that a lack of knowledge and negative attitudes could negatively impact the quality of TB care. In a survey by Shrestha et al.¹⁰ on 190 HCWs in Nepal, TB infection control knowledge, attitudes, and practices were assessed. The study found that while HCWs generally had a positive attitude towards TB, there were significant knowledge and practice gaps, particularly among non-medical personnel. It is expected that stigmatising attitudes and behaviours in non-physician auxiliary healthcare personnel will decrease with increasing levels of education and knowledge about the disease. Frequent and intensive patient contact among healthcare personnel working as midwives, nurses, and nursing assistants may explain their stigmatisinging attitudes and behaviors.

The stigma hindrance to TB patients’ access to healthcare is well-documented. Chen et al.⁴ noted that TB-related stigma often leads patients to neglect other health needs, thereby restricting access to general healthcare services. Bresenham et al.⁵ highlighted that such stigma during TB care processes results in exclusion from essential medical services. This perpetuates health inequities and conflicts with the ethical principles of healthcare provision. Nyblade et al.⁸ emphasized the discriminatory impact of stigmatizing attitudes on treatment processes, underscoring the need for interventions and awareness programs to address these challenges.^{6, 12}

Analyses based on the type of institution revealed that healthcare professionals working in public institutions have lower stigmatization scores, while those in private medical practices (e.g., private clinics, independent pharmacies, and dental treatment centers) have higher stigmatization scores. The World Health Organization’s ‘Ethics Guidance for the Implementation of the End TB Strategy’ offers several key recommendations for private healthcare institutions. These include encouraging private healthcare providers to integrate with national TB programs, adhere to standard treatment protocols, and participate in public health reporting. Additionally, private institutions are advised to engage in TB awareness campaigns and support patient-centered approaches.¹¹ While there is a scarcity of studies in the literature that specifically examine the stigmatizing behaviors and attitudes of healthcare professionals towards certain disease groups, research on TB and human immunodeficiency virus-related stigma generally highlights that working in public institutions is linked to higher participation in in-service training, which in turn enhances awareness of specific disease groups.^{9, 10, 12} The perception among healthcare professionals that the diagnosis and treatment of TB is primarily the responsibility of public healthcare providers may contribute to the stigmatizing attitudes and behaviors observed in individual and private healthcare settings. The NWFI rankings of responses to our survey questions support this notion. For example, in Question 10, participants believed that TB cases should complete their TB treatment before addressing other health issues (NWFI -0.460); in Question 5, participants showed a tendency to refer TB cases to specialized TB centers even when these cases fell within their own specialty and scope of work (NWFI -0.406); in Question 9, participants indicated that TB cases should complete the entire treatment process in sanatorium-type hospitals (NWFI -0.235); in Question 16, participants expressed discomfort with encountering TB cases in the workplace (NWFI -0.110); and, finally, in Question 11, participants mentioned challenges in admitting TB patients for treatment of comorbidities in the hospitals where they work (NWFI -0.067).

Analyses based on the annual number of cases show that HCWs who see more cases have higher stigmatization scores. Notably, HCWs who handle more than 100 cases per year have the highest stigmatization scores. This finding suggests that the stigmatizing behaviors of HCWs increase with their intense workload and frequent patient contact. Supporting this, survey responses indicated: in Question 2, the need for more disinfection than usual after encountering a TB case (NWFI -1.00) was identified as the highest stigmatizing attitude; in Question 3, the unconscious tendency to treat TB cases differently due to the risk of infection (NWFI -0.561); in Question 1, concerns about risking health while examining a TB patient (NWFI -0.531); and in Question 17, a preference for communicating with the relatives of TB patients rather than the patients themselves (NWFI -0.373). In Question 6, the belief that TB cases are contagious, even when using surgical masks, (NWFI -0.177) was also highlighted as a stigmatizing attitude. This aligns with findings from a study by Vigenschow et al.¹³, which examined knowledge, attitudes, and practices regarding TB among 103 HCWs in the Moyen-Ogooué region of Gabon. In their study, 72.8% of HCWs reported fearing TB infection, and 63.1% viewed TB as a stigmatizing disease. These results emphasize the importance of supporting and training HCWs in managing infectious diseases such as TB.

Due to the absence of studies in the literature investigating the stigma levels of healthcare professionals, a study design based on clinicians’ observations was used instead of a standardized stigma scale.

CONCLUSION

HCWs have exhibited stigmatizing attitudes and behaviors towards TB cases, primarily due to concerns about infection transmission, lack of awareness that TB can be diagnosed and treated in public institutions, and the increased caseload that elevates the risk of transmission. Enhancing the TB knowledge of HCWs through formal education and in-service training programs, along with implementing measures that prioritize employee health and reduce infection transmission, can help mitigate these stigmatizing attitudes and behaviors.